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| Знайдено в інших БД: | Реферативна база даних (12) |
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Загальна кількість знайдених документів : 7 Представлено документи з 1 до 7 |
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| 1. | 
Nesina I. P. The study of chromosomal instability in patients with endometrial cancer [Електронний ресурс] / I. P. Nesina, N. P. Iurchenko, S. V. Nespryad’ko, L. G. Buchynska // Experimental oncology. - 2014. - Vol. 36, № 3. - С. 202-206. - Режим доступу: http://nbuv.gov.ua/UJRN/EOL_2014_36_3_12 Aim - study is devoted to evaluation of sensitivity of peripheral blood T-lymphocytes (PBL) of patients with endometrial cancer (EC) to genotoxic effect of bleomycin and detection of patients with hidden chromosomal instability. Methods: PBL of 24 EC patients (mean age 58,9 +- 2,9) and 10 healthy women-volunteers (mean age 55,7 +- 2,3) were subjected to cytogenetic analysis. Mean spontaneous level of chromosomal aberrations (CA) per 100 analyzed lymphocytes (CA/100) of healthy women has equaled 2,7 +- 0,6, i.e. has not exceeded maximal values of healthy population and was significantly lower (p << 0,05), than in PBL of EC patients (6,9 +- 0,6). After incubation of PBL with bleomycin, number of CA/100 significantly was increased both in control (11,5 +- 1,3) and in EC patients (21,9 +- 1,0). Spontaneous chromosomal instability has been observed in 41,7 %, increased sensitivity to bleomycin - in 54,2 % and hidden chromosomal instability in 37,5 % of patients with EC. It has been shown that level of specific damage of genome in EC patients has constituted 2 x 10-5, and after exposure with bleomycin, it was increased 4,5 times (9 x 10-5), that was significantly higher (p << 0,05) compared to control (8 x 10-6 and 1,0 x 10-5, respectively). Conclusion: these results have demonstrated, that PBL of most patients with EC are characterized by apparent genome alterations, which are manifested by increased number of spontaneous and induced chromosomal damages, hypersensitivity to mutagens and hidden chromosomal instability. | ||
| 2. |
Glushchenko N. M. Risk assessment of cancer of the female reproductive system [Електронний ресурс] / N. M. Glushchenko, I. P. Nesina, N. P. Iurchenko, L. A. Proskurnya, L. G. Buchynska // Experimental oncology. - 2014. - Vol. 36, № 3. - С. 207-211. - Режим доступу: http://nbuv.gov.ua/UJRN/EOL_2014_36_3_13 Aim - to create an information resource concerning multifactorial oncological diseases of (he female reproductive system. A comprehensive search of the literature in the PubMcd and Ukrainian scientific sources published from 1995 to 2014 and the results of researches performed in R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine. Development environment of information resource "Multifactorial oncological disease" was Borland Delphi. The information content of web page concerning cancers of the female reproductive system was posted in the information resource "Multifactorial oncological disease". The assessment algorithm of genetic contribution to cancers of the female reproductive system and recurrent risk of cancer development in families have been described. These algorithms can be used in assessment of contribution of genetic and environmental factors in the development of malignant tumors. | ||
| 3. | 
Kryuchko T. O. Modern approaches to antivirulent therapy of diseases associated with Staphylococcus Aureus [Електронний ресурс] / T. O. Kryuchko, O. Ya. Tkachenko, N. V. Kuzmenko, I. N. Nesina, S. M. Tanianska, I. A. Kolenko, M. O. Melnyk // Проблеми екології та медицини. - 2019. - Т. 23, № 3-4. - С. 26-31. - Режим доступу: http://nbuv.gov.ua/UJRN/petm_2019_23_3-4_9 | ||
| 4. | 
Bubyr L. M. Endoscopic and morphological characteristics of the upper gastrointestinal tract in children with food hypersensitivity [Електронний ресурс] / L. M. Bubyr, T. O. Kryuchko, I. M. Nesina, B. M. Filenko, T. O. Pedchenko // Здоров'я дитини. - 2021. - Т. 16, № 2. - С. 145-151. - Режим доступу: http://nbuv.gov.ua/UJRN/Zd_2021_16_2_9 In pediatric practice, increasing attention has been recently paid to the study of allergic disorders in various parts of the gastrointestinal tract, and a number of unresolved issues regarding the timely diagnosis and treatment of eosinophilic lesions of the digestive system determines the relevance of this topic. The purpose of the research was to study the endoscopic and morphological changes of the upper gastrointestinal tract in children with gastrointestinal symptoms of food hypersensitivity. The study enrolled 34 children aged from 6 to 15 years with clinical signs of disorders of the upper digestive tract against the background of food hypersensitivity reactions. Depending on the level of total IgE, study participants were divided into two groups. The first group consisted of 18 children with IgE-independent allergic reactions to food (Me (Q1 - Q3) 35,0 (28,0 - 77,5)). The second group included 16 patients with IgE-induced allergic manifestations of food hypersensitivity (Me (Q1 - Q3) 240,5 (158,0 - 475,8)). To achieve the aim of the research, all children underwent fibroesophagogastroduodenoscopy with subsequent sampling and morphological evaluation of biopsy specimen. According to the results of endoscopic examination of patients, the structure of lesions of the upper gastrointestinal tract depending on the predominance of IgE-independent or IgE-mediated gastrointestinal symptoms of food hypersensitivity did not have statistically significant differences. Morphological characteristics had some differences in the study groups and were represented by the prevalence of eosinophilic infiltration in children with IgE-induced food hypersensitivity reactions. Conclusions: the isolated gastric lesions prevailed in the endoscopic presentation of children with gastrointestinal manifestations of food allergy, and morphological signs of chronic gastritis are characterized by changes in the surface epithelium due to pronounced polymorphonuclear inflammatory infiltration in the lamina propria with a predominance of lymphocytes, neutrophils and plasma cells. The degree of activity of the eosinophilic inflammatory process was more pronounced in the group of children with IgE-induced food hypersensitivity reactions (r = 0,652; p << 0,01). | ||
| 5. | 
Kryuchko T. O. Relationship between indices of cytokine status and pathomophological changes of the mucosa in children with chronic gastroduodenal pathology [Електронний ресурс] / T. O. Kryuchko, I. M. Nesina, L. M. Bubyr, O. Ya. Tkachenko, O. A. Poda, N. V. Kuzmenko, L. Yu. Kryvoshapka // Світ медицини та біології. - 2021. - № 2. - С. 69-73. - Режим доступу: http://nbuv.gov.ua/UJRN/S_med_2021_2_15 | ||
| 6. | 
Kuzmenko N. V. Perception of readiness of future doctors for professional activities and determination of key factors affecting readiness to work [Електронний ресурс] / N. V. Kuzmenko, T. A. Ivanytska, O. A. Poda, I. M. Nesina, S. M. Tanianska // Вісник проблем біології і медицини. - 2023. - Вип. 1. - С. 246-253. - Режим доступу: http://nbuv.gov.ua/UJRN/Vpbm_2023_1_34 | ||
| 7. |
Kryuchko T. O. Difficulties in diagnosing gastrointestinal allergy in paediatric practice: a clinical case [Електронний ресурс] / T. O. Kryuchko, L. M. Bubyr, O. A. Poda, I. M. Nesina, L. A. Kovalenko, D. S. Matiazh // Здоров'я дитини. - 2022. - Т. 17, № 8. - С. 411-415. - Режим доступу: http://nbuv.gov.ua/UJRN/Zd_2022_17_8_9 Since allergy pathology in the structure of general somatic diseases occupies a significant niche in both adult and child populations and is accompanied by a number of unresolved issues, it represents a major medical and social problem. The use of modern diagnostic techniques has made it possible to broaden scientists' knowledge of the in-depth mechanisms of the pathogenesis of allergic diseases with the subsequent development and implementation of new diagnostic, therapeutic and prophylactic recommendations. However, the multidisciplinary aspects of paediatric allergy continue to be studied; among them, the problems of specific diagnosis of food allergy are of particular importance. Recently, the study of allergic lesions in the various parts of the gastrointestinal tract has received increasing attention in paediatric practice. Since in most cases the mucosa of the digestive system is the first to contact with allergens of various nature, the gastrointestinal form ranks second in the overall structure of clinical symptoms of food allergy. Gastrointestinal symptoms of food allergy are characterized by polymorphic manifestations, making timely verification of the diagnosis difficult. This leads to prolonged differential analysis and requires the exclusion of concomitant organic and functional gastrointestinal pathology, which delays early diagnosis and timely therapeutic recommendations for patients with food allergy. The relevance of the above-mentioned problem is highlighted by the following clinical case. | ||
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